{"id":367,"date":"2022-06-13T13:36:04","date_gmt":"2022-06-13T13:36:04","guid":{"rendered":"https:\/\/dposada.webs.uvigo.es\/?p=367"},"modified":"2023-10-12T19:19:37","modified_gmt":"2023-10-12T17:19:37","slug":"phylogenetic-origins-of-relapse-using-single-cell-data","status":"publish","type":"post","link":"https:\/\/gxb.webs.uvigo.es\/?p=367","title":{"rendered":"phylogenetic origins of relapse using single-cell data"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\" id=\"p0010\">Our phylogenetic analysis of single cells exposes how, where and when malignant cells survive treatment in a personalized manner in a liver relapse of a CRC metastasis. We show that the relapse originated from the expansion of a single metastatic lineage that slowly evolved in the liver. Interestingly, there is a clear contribution of chemotherapy exposure to the overall mutational burden of the relapse<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0304383522002518\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0304383522002518<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/dposada.webs.uvigo.es\/wp-content\/uploads\/2022\/06\/image.png\" alt=\"\" class=\"wp-image-368\" width=\"518\" height=\"602\"\/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Our phylogenetic analysis of single cells exposes how, where and when malignant cells survive treatment in a personalized manner in a liver relapse of a CRC metastasis. We show that the relapse originated from the expansion of a single metastatic lineage that slowly evolved in the liver. Interestingly, there is a clear contribution of chemotherapy &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/gxb.webs.uvigo.es\/?p=367\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;phylogenetic origins of relapse using single-cell data&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[45],"tags":[],"class_list":["post-367","post","type-post","status-publish","format-standard","hentry","category-papers"],"jetpack_publicize_connections":[],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pag62I-5V","jetpack-related-posts":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/gxb.webs.uvigo.es\/index.php?rest_route=\/wp\/v2\/posts\/367","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gxb.webs.uvigo.es\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gxb.webs.uvigo.es\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gxb.webs.uvigo.es\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/gxb.webs.uvigo.es\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=367"}],"version-history":[{"count":1,"href":"https:\/\/gxb.webs.uvigo.es\/index.php?rest_route=\/wp\/v2\/posts\/367\/revisions"}],"predecessor-version":[{"id":630,"href":"https:\/\/gxb.webs.uvigo.es\/index.php?rest_route=\/wp\/v2\/posts\/367\/revisions\/630"}],"wp:attachment":[{"href":"https:\/\/gxb.webs.uvigo.es\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=367"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gxb.webs.uvigo.es\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=367"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gxb.webs.uvigo.es\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=367"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}