News

We’ve just secured funding from the Spanish Ministry of Science for our project: “Genomic and Transcriptomic Drivers of Adaptation in Cancer Evolution.” Cancer cells can develop traits such as rapid growth, immune evasion, and drug resistance—not only through DNA mutations but also by altering gene expression. Using single‑cell DNA and RNA sequencing, we’re exploring how tumor cell lineages adapt to new environments, focusing on papillary thyroid and colorectal cancers. Our goal: uncover how phenotypic plasticity and heritable changes fuel cancer progression, paving the way for better diagnosis and therapy

We published a study in Nature Communications identifying connexin43 (Cx43) as a new therapeutic target in BRAF-mutant tumors such as melanoma, colorectal cancer, and breast cancer. Restoring Cx43 enhances the efficacy of BRAF/MEK inhibitors and can reverse drug resistance. The team also developed a patented mRNA-based therapy delivered through nanovesicles.

https://www.nature.com/articles/s41467-025-60971-3

On January 10, Carlos López Solarat successfully defended his doctoral thesis, entitled “Molecular Mechanisms and Phenotypic Diversity in Bardet–Biedl Syndrome”, earning the highest distinction, cum laude, with international recognition.

He will shortly join the laboratories of Drs. Semple and Mill at the University of Edinburgh, UK, where he will continue his research career thanks to a postdoctoral fellowship awarded by the Xunta de Galicia.

Congratulations to Carlos on this outstanding achievement, and best wishes for this exciting new chapter in his scientific career!

New study, published in Nano Materials Science as part of the European PERSEUS project, presents a green, one-step method to synthesize mesoporous platinum nanoparticles using riboflavin, a natural photosensitizer, for light-activated cancer therapy.

The nanoparticles showed strong antitumoral effects against lung cancer cells, with UV-A irradiation enhancing the activity of riboflavin- and lumichrome-based nanoparticles through oxidative stress.

Learn more here:

https://www.investigo.biblioteca.uvigo.es/xmlui/handle/11093/8481

María Mayán, a CINBIO researcher, and her team of PhD and postdoctoral students have joined the GXB group. We are very happy about this incorporation. We will update the web as soon as possible!