GXB research group @ University of Vigo
Our recent studies show that evolutionary constraints imposed by protein structure affect phylogenetic inferences and must be considered when evaluating how specific mutations affect the stability and function of viral proteins.
https://onlinelibrary.wiley.com/doi/10.1002/prot.70183
https://academic.oup.com/sysbio/article/75/3/581/8118925
We are proud to announce that the Xunta de Galicia continues to support the Genomics and Biomedicine Group (GXB) at the University of Vigo as a Competitive Reference Group within the Center for Biomedical Research (CINBIO), a Singular Research Center recognized by the Galician Government.
This continued support enables us to advance our research in three key areas: disease and pathogen genomics, molecular biology applied to biomedicine, and nanomaterials in biomedicine.
We are grateful for this ongoing commitment, which strengthens our ability to pursue cutting-edge research with real impact on health and disease.
María Mayán received the VIII FERO Grant in Breast Cancer, endowed with 100,000 euros, at the FERO Gala 2026 in Barcelona. The project, “CAR-NK immunotherapy with improved tumor-targeting capabilities”, aims to improve how genetically modified NK cells reach and destroy solid breast tumors. It will be carried out in collaboration with the Álvaro Cunqueiro Hospital and researchers in Oslo.
Excited about biomedical research? Come work with us!
TALENTGAL (MSCA-COFUND) has 40 postdoc fellowships open NOW — 30 months, fully funded, interdisciplinary!
3 potential positions at CINBIO.
• Molecular & Immune Mechanisms in Precision Oncology
• AI-driven Biomedical Data Analysis
• Multiomic Approaches for Next-Gen Therapeutics
Deadline: July 23, 2026
Applicants must meet the following criteria:
New in Genome Medicine! Deep genomic analysis of relapsed colorectal cancer liver metastases reveals patient-specific evolutionary trajectories and multiple routes to recurrence.
Laura Tomás at our lab led the hands‑on, multi‑omic analysis
Nice collaboration with @soulafa.bsky.social & colleagues
https://link.springer.com/article/10.1186/s13073-026-01614-0
To mark the International Day of Women and Girls in Science, the GXB organized an outreach event promoted by the UCC+i (Scientific Culture and Innovation Unit). The team collaborated with CEIP Plurilingüe Nº 1 in Tui on a workshop dedicated to soil scientist Benita Silva Hermo, a pioneer in studying granite in Galician monuments and its biological colonization. Under the guidance of biologist Ledicia Taboada, chemist Sonia Barreiro, and GXB researcher Iria Fernández Silva, 1st- and 2nd-grade students learned to identify the most common rocks and minerals and their applications. The activity concluded with an educational field trip to explore the Church of Santo Domingo’s granite architectural heritage and observe the biodiversity that colonizes it. In this way, students discovered the honoree’s legacy while connecting geology to the history of their own municipality.
In January 2026, we launched a new project funded by the Instituto de Salud Carlos III (ISCIII) entitled “A Holistic Study of Inherited Retinal Dystrophies Using Omics, Bioinformatics and AI Technologies for Molecular, Clinical and Demographic Characterisation.”
This coordinated project brings together research teams from the University of Vigo, Fundación Jiménez Díaz (Madrid), and La Fe University Hospital (Valencia), with the participation of Dr Ayuso and Dr Millán.
The contribution of the GXB group focuses on understanding the genetic and molecular mechanisms underlying Bardet-Biedl syndrome and Alström syndrome, two rare ciliopathies associated with inherited retinal dystrophies. We will investigate the role of mitochondrial dysfunction and autophagy in disease development and clinical variability, building on our previous findings and established cellular models.
Through this research, we aim to advance our understanding of these conditions and contribute to improved patient characterisation, stratification and future personalised therapeutic strategies.
We found that forecasting viral protein evolution is possible in some scenarios, but the models still need improvement to increase prediction accuracy.
https://elifesciences.org/articles/106365
Iria Fernández-Silva has visited the prestigious California Academy of Sciences to deepen her research on genomic hybridization in marine fish. During her stay, she used the institution’s exceptional fish collection, which houses more than 2,000,000 specimens, and visited the CCCG genomics laboratory to see recent infrastructure improvements. This international exchange continues a collaboration that began in 2013 and provides a strong boost to ongoing research lines, contributing key data on the evolution and conservation of ocean biodiversity.
We’ve just secured funding from the Spanish Ministry of Science for our project: “Genomic and Transcriptomic Drivers of Adaptation in Cancer Evolution.” Cancer cells can develop traits such as rapid growth, immune evasion, and drug resistance—not only through DNA mutations but also by altering gene expression. Using single‑cell DNA and RNA sequencing, we’re exploring how tumor cell lineages adapt to new environments, focusing on papillary thyroid and colorectal cancers. Our goal: uncover how phenotypic plasticity and heritable changes fuel cancer progression, paving the way for better diagnosis and therapy
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